| Recommendations for Immediate type allergy | Strength | Quality of evidence |
| 1. We recommend that patients with a suspected or proven immediate type allergy to penicillins can receive cephalosporins, but only those with dissimilar side chains, irrespective of severity and time since the index reaction. | Strong | Moderate |
| 2. Cefazolin does not share any side chains with the currently available penicillins and can be used in cases of suspected or proven immediate type allergy to a penicillin, irrespective of severity or time since the index reaction. | Strong | Moderate |
| 3. We suggest that patients with a suspected or proven non-severe, immediate type index reaction to a penicillin >5 years ago, can receive a therapeutic dose of cephalosporins with similar side chains in a controlled setting*. | Weak | Low |
* A clinical setting, in which the patient is observed, with trained personnel, where rapid and adequate treatment can be administered when an allergic reaction occurs.
Bron: SWAB guideline for the approach to suspected Antibiotic Allergy, 2022. Richtlijn downloaden: 192 (swab.nl)